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Showing Tag: "txa" (Show all posts)

Pre-hospital TXA for trauma - The STAAMP Trial

Posted by Matthew Mac Partlin on Tuesday, October 13, 2020, In : Clinical topics 

Tranexamic acid (TXA) is an antifibrinolytic medication that displaces plasminogen from the fibrin complex which should result in a more persistent clot. Given that the majority of trauma deaths are due to haemorrhage, this would seem to be a reasonable therapeutic target.

TXA has established use in the management of epistaxis and postpartum haemorrhage (1) . The CRASH-2 (2) and MATTERS (6) trials demonstrated mortality benefit in trauma patients at risk of bleeding by adding TXA to the ...

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Tranexamic acid in trauma

Posted by Matthew Mac Partlin on Saturday, January 18, 2014, In : Clinical topics 
Posted by Matthew Mac Partlin on Monday, March 5, 2012

The use of Tranexamic Acid in truamatic haemorrage has been gaining increasing attention since the publication of the CRASH-II trial in 2010. Tranexamic acid (TXA) is an antifibrinolytic, meaning that it prevents the breakdown of clot that has already formed. This is different to the commonly used FFP and prothrombin complex concentrates (PCC), which provide clotting factors to facilitate clot formation and the much more expensive Factor ...
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